According to the official club website, Antony, Harry Maguire and Anthony Martial are all doubtful to feature when Barcelona arrive at Old Trafford for the second leg of the Europa League knockout tie this week.
Scott McTominay appeared as a substitute in the 3-0 thrashing of Leicester City, meaning he could be available once again.
Meanwhile, Christian Eriksen and Donny van de Beekare ruled out as they recover from long-term injuries.
More good news for Manchester United is that Lisandro Martinez and Marcel Sabitzer are both available after missing the first leg through European bans.
